By Juliette Jabkhiro and Michel Rose
PARIS&nbsp;(Reuters) -A&nbsp;blast&nbsp;ripped through a street near&nbsp;Paris' historic Latin Quarter on Wednesday and rescuers were searching for two missing people feared buried&nbsp;under&nbsp;the&nbsp;rubble&nbsp;of a building that partially collapsed in the explosion.
The explosion tore through Rue Saint-Jacques, which runs from the Notre-Dame de&nbsp;Paris&nbsp;Cathedral to the Sorbonne University, in the late afternoon, injuring at&nbsp;least&nbsp;37&nbsp;people, four of whom were fighting for their lives in hospital.
Interior Minister Gerald Darmanin said that&nbsp;sniffer&nbsp;dogs&nbsp;had&nbsp;picked&nbsp;up&nbsp;a&nbsp;scent&nbsp;under&nbsp;the mound of masonry left strewn across Rue Saint-Jacques.
"It is possible tonight that we will find bodies or perhaps survivors," Darmanin told reporters at the scene of the&nbsp;blast.
The&nbsp;blast&nbsp;destroyed the facade of a building housing the&nbsp;Paris&nbsp;American Academy design school popular with foreign students.
Witnesses described a deafening explosion and a giant fireball that rose several stories high.
Soldiers helped secure a safety cordon around the scene.
The&nbsp;Paris&nbsp;prosecutor's office said it was too early to say what caused the&nbsp;blast.
But the local deputy mayor, Edouard Civel, referred to a gas explosion in a Twitter post and witnesses told BFM TV there had been a strong smell of gas moments before the&nbsp;blast.
"The shop shook violently, it felt like bomb&nbsp;blast," said Rahman Oliur who manages a food shop a few doors down the street from the American Academy.
Bar worker Khal Ilsey said he heard a "huge explosion" before running out and seeing a violent blaze at the end of the street.
RUBBLE&nbsp;AND FIRE
The&nbsp;blast&nbsp;occurred at 4:55 p.m. (1455 GMT), just as workers were heading home. The area is frequented by tourists and foreign students in the early summer but there was no immediate indication that any foreigners were among the victims.
Several nearby building were evacuated. More than two hours after the explosion, first responders were still treating residents for shock. One woman fainted in the street.
Paris&nbsp;Prosecutor Laure Beccuau said early indications were that the&nbsp;blast&nbsp;originated inside the collapsed building. Investigators would look into whether building conditions were in breach of regulations or if an individual had acted without due care, he added.
More than 300 firefighters were involved in bringing the blazes&nbsp;under&nbsp;control.
Rue Saint-Jacques runs through the Latin Quarter - famed as the home to many expatriate and French writers, musicians and artists over the years - to the Val de Grace military hospital and is a few blocks from the popular Jardin du Luxembourg.
"I was at home writing ... I thought it was a bomb," said art historian Monique Mosser, adding that many of the windows in her building had been blown out by the&nbsp;blast's shockwave.
"A neighbour knocked on the door and told me that the fire brigade were asking us to evacuate as quickly as possible. I grabbed my laptop, my phone. I didn't even think to take get my medication."
In January 2019, a gas leak caused an explosion that killed 4 people and injured 66 in the 9th arrondissement. In April that year, a fire broke out in the Notre-Dame Cathedral, destroying much of the roof and causing other damage before it was extinguished.
(Reporting by Michel Rose, Sudip Kar-Gupta, Tassilo Hummel, Juliette Jabkhiro, Elizabeth Pineau;Editing by Jean-Michel Belot, Tassilo Hummel, Angus MacSwan and Sandra Maler)

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Paris blast: At least 37 hurt, sniffer dogs pick up scent under rubble